Endocrine Abstracts

The secretion of leptin, an indicator of energy reserves, declines as energy stores are consumed in growth and development at puberty. The pubertal growth and development are often altered under different kinds of stresses. Usually, stress stimulates the release of cortisol, which is a labelled marker of stress. Early teens are inclined to drug abuse that may put their bodies under stress and may induce excessive secretion of cortisol. Since, sustained high levels of cortisol ...

Introduction: The triad of diabetic ketoacidosis (DKA), acute pancreatitis (AP), and hypertriglyceridaemia (HTG) has been described mainly in T1DM with few cases in T2DM. We report the first case of this triad revealing T2DM.Case report: A 30-year-old male with strong family history of T2DM presented to the emergency with severe epigastric pain radiating to the back associated with abdominal swelling, vomiting and diarrhea. He also reported history of po...

We previously reported a case of non islet cell tumour hypoglycaemia (NICTH) due to increased ‘big’-IGF2 production in a lady with haemangiopericytoma (HAP). We now describe the challenges in managing this lady who had recurrent, disabling hypoglycaemia requiring frequent hospitalisation.This patient presented with symptomatic hypoglycaemia 15 years after the diagnosis of parasaggital HAP. At presentation she had tumour recurrence with liver an...

Introduction: Spontaneous hypoglycaemia is very rarely related to non-islet cell tumours. Most of them are due to mesenchymal tumours including haemangiopericytoma (HAP). It has been reported that, in patients with NICTH who have inoperable tumours, high doses of glucocorticoid or recombinant human growth hormone may be effective in treating hypoglycaemia. We present, with relevant imaging, a rare case of metastatic HAP causing an increased level of insulin like growth factor ...

Introduction: Vitiligo is an acquired depigmenting disorder due to destruction of melanocytes. Most authorities believe that the most important pathogenetic mechanism of the disease is autoimmunity. Other autoimmune disorders such as thyroid autoimmune diseases occur commonly in association with vitiligo. This study was designed to determine the role of thyroid ultrasonography as a noninvasive and cost effective diagnostic method for early detection of thyroid disorders in pat...

Introduction: Obesity and its related diseases like high blood pressure are the main reason of coronary heart diseases that are the second main cause of mortality in I.R of IRAN. The significant rise of obesity in the last decade resulted in corresponding increase in the prevalence of hypertension.Objective: To detect obesity and hypertension, and the relationship between them among Semnanian people, Iran, 2007Methods: In this cros...

Introduction: Strontium ranelate (SR) is a dual action bone agent that increases bone formation and reduces bone resorption. Previous long term studies with SR have demonstrated minimal reductions in parathyroid hormone (PTH) and adjusted calcium (ACa) levels with increase in phosphate (PO4) concentrations, but the exact mechanism of action of SR remains unclear. Postmenopausal women with low bone mineral density (BMD) have relatively high circulating PTH concentrat...

Introduction: The beneficial effect of GH replacement on bone in AGHD patients is mediated by improvements in target organ sensitivity to PTH and phosphocalcium metabolism. In aging women with established osteoporosis, GH and IGF-1 concentrations are lower and administration of GH has been shown to increase bone turnover and BMD, but the mechanisms remain unclear.Methods: Fourteen postmenopausal women (63.4±2.1 years; mean BMD T score ± ...

Rhythmic, timed secretion of ghrelin and leptin is integral to the intricate temporal interplay of hormonal signals that maintains energy balance, feeding and body weight. Growth hormone replacement (GHR) in adult growth hormone deficient (AGHD) patients has been shown to alter body composition, energy balance and insulin sensitivity with changes in leptin secretory pattern and concentration. With GHR, single time point ghrelin concentrations have been shown to either increase...

PTH plays an important role in bone metabolism. Active acromegaly is associated with increased bone turnover. Reduction in bone turnover markers occurs following biochemical cure/control of acromegaly. We examined the effect of active acromegaly and its treatment on PTH concentration and PTH target-organ sensitivity.10 patients with active acromegaly (defined as GH nadir greater than 1mU/L following 75g oral glucose load and IGF1 above reference range) a...